Our Process

Four core platforms enable CDI to develop proprietary stabilizers. A licensee needs only to send us their current products without chemical stabilizers (see contact information).

The process is as follows:

First, we use proprietary diagnostics products (PDPs) to allow us to identify the complexity and interwoven biochemical mechanisms that are impacting stability. PDPs are used to detect and verify the complexity and source(s) of instability in our licensee’s products. Second, the PDPs are combined with the sample on a customized high throughput array. Next, we employ our proprietary calibrated aging accererator (CAA) to rapidly age the sample (10x to 1000x) to simulate real time aging. Finally, more than 300 GRaS components are screened to develop a customized stability formulation for each product. From start to finish the CDI process takes less than 45 days to develop a proprietary natural stabilizer or preservative.

Products:

Urine Controls (Announcing Greater Urine Controls & Shelf-Life Stability) New stabilizer (CDI-PSP-UE1) CDI-customized procedure & product to treat urine before controls are added, including:

Urine Pasteurization Procedure
PSP-UE1 (proprietary CDI product to reduce key molecule degradation)

Analysis of reactive agents:

Hydrogen peroxide at t=0, (2 to 6 µM) which quickly disappeared
Adfter storage for 15 days at 47°C, Hydrogen Peroxide levels declined to nM levels (20 to 70 nM ).

Hydrogen Peroxide generation and stability is dependent upon a variety of environmental factors, i.e. oxidative generation processes, radical sources, pH, thermal, and inactivating reagents (peroxide & radical scavengers).

In the presence of peroxide generators, elevated temperatures may be expected to increase peroxide levels.
Upon exhaustion of peroxide sources, thermal decomposition of hydrogen peroxide may anticipated
As a result hydrogen peroxide levels may very well follow a bell shaped curve as a function of time and temperature, i.e. increasing initially followed by an eventual decline.
Hydrogen peroxide generation is often associated with radical formation which can in turn initiate a cascade of oxidative and decomposition processes.

Reducing peroxide levels and is important for stability for all urine control products (due to general oxidation processes).

Peroxide content increases significantly upon longer term exposure.
Thermal pasteurization alone is not sufficient to reduce peroxide.